Direct and Sequential Bioactivation of Pemigatinib to Reactive Iminium Ion Intermediates Culminates in Mechanism-Based Inactivation of Cytochrome P450 3A
Lloyd Wei Tat Tang, Wei Wan, Ravi Kumar Verma, Siew Kwan Koh, Lei Zhou, Hao Fan, Eric Chun Yong Chan
Topics & Concepts
ChemistryMetaboliteCytochrome P450StereochemistryMetabolismBiochemistryPharmacogenetics and Drug MetabolismFibroblast Growth Factor ResearchPI3K/AKT/mTOR signaling in cancer