Flexible Microneedle Array Patch for Chronic Wound Oxygenation and Biofilm Eradication
Ian Woodhouse, Sina Nejati, Vidhya Selvamani, Hongjie Jiang, Shirisha Chittiboyina, Jesse Grant, Zeynep Mutlu, Jose Waimin, Nader S. Abutaleb, Mohamed N. Seleem, Rahim Rahimi
Abstract
) bacterial strains commonly found in dermal wounds. Furthermore, the results from the ex vivo assay on a porcine wound model indicated successful insertion of the microneedles into the tissue while also providing effective bactericidal properties against both Gram-positive and Gram-negative within the complex tissue matrix. Additionally, the microneedles demonstrate high levels of cytocompatibility with less than 10% of apoptosis throughout 6 days of continuous exposure to human dermal fibroblast cells. The demonstrated flexible microneedle array can provide a better approach for increasing the effectiveness of topical tissue oxygenation as well as the treatment of infected wounds with intrinsically antibiotic resistant biofilms.