The Roles of miRNAs in Predicting Bladder Cancer Recurrence and Resistance to Treatment
Sanjna Das, Joshua P. Hayden, Travis Sullivan, Kimberly Rieger‐Christ
Abstract
Bladder cancer (BCa) is associated with significant morbidity, with development linked to environmental, lifestyle, and genetic causes. Recurrence presents a significant issue and is managed in the clinical setting with intravesical chemotherapy or immunotherapy. In order to address challenges such as a limited supply of BCG and identifying cases likely to recur, it would be advantageous to use molecular biomarkers to determine likelihood of recurrence and treatment response. Here, we review microRNAs (miRNAs) that have shown promise as predictors of BCa recurrence. MiRNAs are also discussed in the context of predicting resistance or susceptibility to BCa treatment.
Topics & Concepts
microRNABladder cancerContext (archaeology)MedicineImmunotherapyCancerOncologyChemotherapyCancer recurrenceResistance (ecology)Internal medicineBioinformaticsBiologyGeneGeneticsPaleontologyEcologyBladder and Urothelial Cancer TreatmentsEpigenetics and DNA MethylationFerroptosis and cancer prognosis