Remote drug loading into liposomes <i>via</i> click reaction
Yaxin Zheng, Lei Xie, Xiaoru Tie, Lei Cao, Qingyuan Li, Yue Quan, Lingfeng Tang, Yang Li
Abstract
antitumor efficacy than free drugs at the equitoxic dose. More importantly, this method is a remote drug loading strategy in nature, which is suitable for industrial production. This is the first demonstration of active loading of MAL-tagged chemotherapeutics in liposomes for improved antitumor efficacies, which has the potential to serve as a universal drug loading strategy for the development of liposomal formulations of chemotherapeutics.
Topics & Concepts
LiposomeClick chemistryDrugMaterials scienceNanotechnologyPharmacologyPolymer chemistryMedicineNanoparticle-Based Drug DeliveryNanoplatforms for cancer theranosticsAdvanced biosensing and bioanalysis techniques