Hypoxia-induced ROS promotes mitochondrial fission and cisplatin chemosensitivity via HIF-1α/Mff regulation in head and neck squamous cell carcinoma
Kun Wu, Yuanyuan Mao, Qi Chen, Bolin Zhang, Sheng Zhang, Hanjiang Wu, Yan Li
Topics & Concepts
Head and neck squamous-cell carcinomaMitochondrial fissionGene knockdownFlow cytometryCisplatinCancer researchApoptosisHypoxia (environmental)MitochondrionChemistryMitochondrial ROSBiologyCell biologyMolecular biologyHead and neck cancerChemotherapyCancerBiochemistryOxygenOrganic chemistryGeneticsCancer, Hypoxia, and MetabolismMitochondrial Function and PathologyATP Synthase and ATPases Research