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Inflammatory cytokines, T lymphocyte subsets, and ritonavir involved in liver injury of COVID-19 patients

Shengtao Liao, Ke Zhan, L. H. Gan, Yang Bai, Jinfang Li, Guodan Yuan, Ying Cai, An Zhang, Song He, Zhechuan Mei

2020Signal Transduction and Targeted Therapy23 citationsDOIOpen Access PDF

Abstract

) is a type of novel coronavirus and no specific treatment is currently available. Apart from damages to the lung, COVID-19 is also able to trigger liver injury. Numerous observational studies have revealed that elevation of liver enzymes, including alanine aminotransferase (ALT) and aspartate aminotransferase (AST), was detected in some COVID-19 patients, especially in severe cases. Therefore, identification of novel risk factors in liver injury of COVID-19 patients is essential for the prevention and treatment of liver damage. In this study, 192 patients with COVID-19 hospitalized in Chongqing Public Health Center were recruited to identify the risk factors in COVID-19 patients with liver injury.

Topics & Concepts

Coronavirus disease 2019 (COVID-19)Ritonavir2019-20 coronavirus outbreakSevere acute respiratory syndrome coronavirus 2 (SARS-CoV-2)Lymphocyte subsetsImmunologyLiver injuryMedicineVirologyLymphocyteT cellPathologyImmune systemViral loadHuman immunodeficiency virus (HIV)PharmacologyOutbreakInfectious disease (medical specialty)DiseaseAntiretroviral therapyCOVID-19 Clinical Research StudiesLiver Disease Diagnosis and TreatmentLong-Term Effects of COVID-19