Novel anti-VEGFR2 antibody-conjugated nanobubbles for targeted ultrasound molecular imaging in a rabbit VX2 hepatic tumor model
Houqiang Yu, Shuanghua Zheng, Wang Cai, Jun Xing, Ling Li
Abstract
In this study, anti-VEGFR2 antibodies were incorporated into uniform-sized (260.9 ± 3.3 nm with a polydispersity index of 0.168 ± 0.036, n = 3) nanobubbles for targeted ultrasound molecular imaging on rabbit VX2 orthotopic hepatic tumors.
Topics & Concepts
Rabbit (cipher)DispersityAntibodyUltrasoundConjugated systemMolecular imagingVEGF receptorsCancer researchPathologyMaterials scienceMedicineRadiologyBiologyImmunologyIn vivoPolymerPolymer chemistryMathematicsBiotechnologyComposite materialStatisticsUltrasound and Hyperthermia ApplicationsUltrasound and Cavitation PhenomenaPhotoacoustic and Ultrasonic Imaging