LIFR-α-dependent adipocyte signaling in obesity limits adipose expansion contributing to fatty liver disease
Tong Guo, Arun Gupta, Jinhai Yu, Jorge Z. Granados, Aakash Y. Gandhi, Bret M. Evers, Puneeth Iyengar, Rodney E. Infante
Abstract
mice. These findings establish the importance of obesity-associated LIFR-α/JAK/STAT3 inflammatory signaling in adipocytes, blocking further adipose expansion in DIO contributing to ectopic liver triacylglyceride accumulation.
Topics & Concepts
AdipocyteLeukemia inhibitory factor receptorAdipose tissueInternal medicineEndocrinologyLipolysisFatty liverSTAT3Leukemia inhibitory factorChemistryAdipogenesisInflammationBiologySignal transductionInterleukin 6MedicineCell biologyDiseaseAdipokines, Inflammation, and Metabolic DiseasesAdipose Tissue and MetabolismImmune Cell Function and Interaction