Extracellular vesicle-mediated spinal cord-brain crosstalk induces hippocampal neurogenesis impairment and cognitive deficits post-spinal cord injury
Tian Qin, Yiming Qin, Yuxin Jin, Xiangyu Liang, Yi Sun, Jianwei Liu, Hongbin Lü, Chengjun Li, Jianzhong Hu, Liyuan Jiang
Abstract
This study uncovers a novel microglia-derived EV-mediated communication axis between the spinal cord and hippocampus following SCI. It identifies the miR-152-3p/WNT10b axis as a key regulator of SCI-induced cognitive dysfunction and impaired neurogenesis. Activation of the WNT pathway was shown to restore neurogenesis and cognitive function, providing valuable insights into therapeutic strategies for SCI-associated cognitive impairments.
Topics & Concepts
NeurogenesisSpinal cordHippocampal formationSpinal cord injuryNeuroscienceMedicineExtracellular vesicleExtracellularPsychologyBiologyCell biologyMicrovesiclesmicroRNABiochemistryGeneExtracellular vesicles in diseaseNeurogenesis and neuroplasticity mechanisms