Downregulation of miR-155-5p enhances the anti-tumor effect of cetuximab on triple-negative breast cancer cells via inducing cell apoptosis and pyroptosis
Wen Xu, Changfeng Song, Xiaotong Wang, Yueqi Li, Xue Bai, Xin Liang, Jingjing Wu, Jianwen Liu
Abstract
experiments confirmed that the downregulation of miR-155-5p enhanced the anti-tumor effect of cetuximab in an MDA-MB-468 xenograft model and on EGFR-overexpressed TNBC cells via inducing cell apoptosis and pyroptosis. Therefore, cetuximab combination with an miR-155-5p antagomir may be a novel therapeutic strategy for the treatment of TNBC.
Topics & Concepts
Triple-negative breast cancerDownregulation and upregulationCetuximabPyroptosisApoptosisCancer researchBreast cancerCancerChemistryMedicineProgrammed cell deathInternal medicineGeneColorectal cancerBiochemistryInflammasome and immune disordersCircular RNAs in diseasesGout, Hyperuricemia, Uric Acid