Water-mediated reduction of [Cu(dmp)<sub>2</sub>(CH<sub>3</sub>CN)]<sup>2+</sup>: implications of the structure of a classical complex on its activity as an anticancer drug
Pedro Levín, María C. Ruiz, Adolfo I. B. Romo, Otaciro R. Nascimento, Ana L. Di Virgilio, Allen G. Oliver, Alejandro Pedro Ayala, Izaura C.N. Diógenes, Ignácio E. León, Luis Lemus
Abstract
[Cu(dmp)<sub>2</sub>(CH<sub>3</sub>CN)]<sup>2+</sup> can be reduced in acetonitrile containing water due to steric constraints of the ligands. Hydroxyl radicals are produced from water oxidation. We take advantage of this reaction to evaluate the anticancer activity of the complex.
Topics & Concepts
ChemistrySteric effectsAcetonitrileRadicalInorganic chemistryMedicinal chemistryStereochemistryCrystallographyOrganic chemistryMetal complexes synthesis and propertiesMetal-Catalyzed Oxygenation MechanismsMagnetism in coordination complexes