Ketone body β-hydroxybutyrate-mediated histone β-hydroxybutyrylation upregulates lipolysis and attenuates metabolic syndrome
Sachin Aryal, Blair Mell, Ishan Manandhar, Beng San Yeoh, Xue Mei, Oluwatosin Mautin Akinola, Wisdom Ahlidja, Bina Joe
Abstract
This is the first study to demonstrate that exogenous β-hydroxybutyrate supplementation attenuates metabolic syndrome (MetS) and identifies histone β-hydroxybutyrylation-mediated chromatin remodeling as one of the mechanisms to upregulate the transcription of the lipid catabolic genes, Hmgcs2, Cyp2d4, Cyp2e1, and Acaa1b. Our work constitutes a strong foundation for the use of 1,3-butanediol as an alternative epigenetic therapeutic for individuals who are physically unable to achieve the MetS lowering benefits of lifestyle modifications such as exercise and intermittent fasting.
Topics & Concepts
LipolysisHistoneEpigeneticsEndocrinologyDownregulation and upregulationInternal medicineMetabolic syndromeBiologyBiochemistryAdipose tissueMedicineGeneObesityDiet and metabolism studiesMetabolism, Diabetes, and CancerAdipose Tissue and Metabolism