Rapid colorimetric sensing of chlorpromazine HCl antipsychotic through <i>in situ</i> growth of gold nanoparticles
Mohammad K. Hammood, Jalal N. Jeber, Maryam Al Khalaf, Haneen abdul hadi kharaba
Abstract
quantification limit and less than 3.5% RSD. The AuNPs exhibited a characteristic surface plasmon resonance band at 527 nm detectable by UV-vis spectrophotometry. Method validation with spiked serum, urine and environmental water samples demonstrated acceptable accuracy and precision. Interfering substances showed minimal impact, indicating resilience and specificity. This rapid, inexpensive colorimetric assay could facilitate environmental monitoring and biomedical analysis of antipsychotic drugs.
Topics & Concepts
Colloidal goldChlorpromazineChemistryNanoparticleIn situHydrochlorideAntipsychoticCombinatorial chemistryNuclear chemistryNanotechnologyMaterials sciencePharmacologyComputer scienceSchizophrenia (object-oriented programming)Organic chemistryMedicineProgramming languageAdvanced biosensing and bioanalysis techniquesAdvanced Nanomaterials in CatalysisBiosensors and Analytical Detection