Anti-inflammatory celastrol promotes a switch from leukotriene biosynthesis to formation of specialized pro-resolving lipid mediators
Simona Pace, Kehong Zhang, Paul M. Jordan, Rossella Bilancia, Wenfei Wang, Friedemann Börner, R. Hofstetter, Marianna Potenza, Christian Kretzer, Jana Gerstmeier, Dagmar Fischer, Stefan Lorkowski, Nathaniel C. Gilbert, Marcia E. Newcomer, Antonietta Rossi, Xinchun Chen, Oliver Werz
Topics & Concepts
CelastrolLipid signalingInflammationChemistryArachidonate 5-lipoxygenaseZymosanTripterygium wilfordiiLeukotriene B4PharmacologyLeukotrieneIn vivoBiochemistryArachidonic acidEnzymeIn vitroImmunologyApoptosisBiologyMedicineAlternative medicineBiotechnologyPathologyAsthmaNatural Compounds in Disease TreatmentSphingolipid Metabolism and SignalingNatural product bioactivities and synthesis