Multi-target rational design and synthesis of novel diphenyl-tethered pyrazolopyrimidines targeting EGFR and topoisomerase II with potential DNA intercalation and apoptosis induction
Ahmed A. Abdel Gaber, Ayman Abo Elmaaty, Marwa Sharaky, Aliaa A. Mosa, Abdullah Yahya Abdullah Alzahrani, Saad Shaaban, Wagdy M. Eldehna, Ahmed A. Al‐Karmalawy
Topics & Concepts
ChemistryEtoposideTopoisomeraseHeLaIntercalation (chemistry)ApoptosisStereochemistryDNADNA fragmentationDNA damageIC50Cancer cellTopoisomerase inhibitorCombinatorial chemistryBiochemistryIn vitroProgrammed cell deathCancerOrganic chemistryInternal medicineMedicineChemotherapySurgeryCancer therapeutics and mechanismsSynthesis and biological activitySynthesis and Biological Evaluation