Multi-omic characterization of antibody-producing CHO cell lines elucidates metabolic reprogramming and nutrient uptake bottlenecks
Saratram Gopalakrishnan, William Johnson, Miguel Á. Valderrama-Gómez, Elçin Içten, Jasmine Tat, Fides D. Lay, Jonathan Diep, Natalia Gómez, Jennitte Stevens, Fabrice Schlegel, Pablo Rolandi, Cleo Kontoravdi, Nathan E. Lewis
Topics & Concepts
BioprocessMetabolomicsBiologyMetabolic flux analysisFlux balance analysisChinese hamster ovary cellMetabolic engineeringComputational biologyContext (archaeology)TranscriptomeSystems biologyMetabolic networkCell biologyMetabolismCell cultureBiochemistryBioinformaticsGeneticsEnzymeGeneGene expressionPaleontologyViral Infectious Diseases and Gene Expression in InsectsMicrobial Metabolic Engineering and BioproductionGene Regulatory Network Analysis