TOPBP1 regulates resistance of gastric cancer to oxaliplatin by promoting transcription of PARP1
Zejun Fang, Chaoju Gong, Zhuoni Ye, Wei Wang, Minjing Zhu, Yanyan Hu, Zhiguo Liu, Weihua Zhou, Hongzhang Li
Topics & Concepts
OxaliplatinPARP1BiologyCancer researchTopoisomerasePoly ADP ribose polymeraseCancerApoptosisCancer cellTranscription factorChemotherapyMolecular biologyBiochemistryColorectal cancerDNAPolymeraseGeneticsGeneCancer therapeutics and mechanismsPARP inhibition in cancer therapyDNA Repair Mechanisms