Acute myeloid leukemia: novel mutations and their clinical implications.
Harshita Makkar, Ravi Kumar Majhi, Harsh Goel, Aditya Gupta, Anita Chopra, Pranay Tanwar, Rachna Seth
Abstract
alters the splicing of downstream mRNA. The systemic influence of these mutations has adverse consequences. Therefore, extensive research on novel mutations and their mechanism of action in the pathogenesis of AML is vital. This study lays out the perspective of expanding the apprehension about AML and novel drug targets. The combination of advanced genetic techniques, risk stratification, ongoing improvements, and innovations in treatment strategy will undoubtedly lead to improved survival outcomes in AML.
Topics & Concepts
MedicineMyeloid leukemiaPTPN11Cancer researchMutationOncologyImmunologyBioinformaticsKRASInternal medicineGeneGeneticsBiologyCancerColorectal cancerAcute Myeloid Leukemia ResearchMyeloproliferative Neoplasms: Diagnosis and TreatmentHistone Deacetylase Inhibitors Research