Self‐photocatalyzed Homolytic Dehalogenative Alkylation/Cyclization of Unactivated Alkenes Based on the Quinazolinone Skeleton via Energy Transfer
Bin Sun, Xiaoli Tang, Rongcheng Shi, Zhiyang Yan, Bingqian Li, Chen Tang, Can Jin, Chunlei Wu, Runpu Shen
Abstract
Abstract A mild, external photocatalyst‐ and additive‐free protocol for photo‐induced alkylation/cyclization of unactivated alkenes with halides has been developed. This strategy showed excellent regioselectivity and simple operation to synthesize alkyl‐substituted quinazolinones with a broad substrate scope. More importantly, chlorinated alkanes were also compatible with this transformation.
Topics & Concepts
ChemistryQuinazolinoneRegioselectivityAlkylationCyclopentanesHomolysisHalideSubstrate (aquarium)Intramolecular forceAlkylCombinatorial chemistryOrganic chemistryRadicalCatalysisOceanographyGeologyQuinazolinone synthesis and applicationsCatalytic C–H Functionalization MethodsRadical Photochemical Reactions