Crossing the blood–brain barrier: advances in dendrimer-based nanocarriers for central nervous system delivery
Priyanshu Bharadwaj, Gaëlle Roullin, Jeanne Leblond Chain
Abstract
F-OP-801, which demonstrate targeted delivery and imaging capabilities in neuroinflammatory and oncological models. Despite these advances, challenges remain in addressing dendrimer-associated toxicity, scalable manufacturing, and the heterogeneity of BBB dysfunction across disease states. Looking ahead, integrating artificial intelligence (AI) for BBB permeability prediction and the adoption of advanced biomimetic and aptamer-based targeting strategies could accelerate the development of next-generation dendrimer therapeutics.
Topics & Concepts
NanocarriersDrug deliveryNanotechnologyComputer scienceTargeted drug deliveryDendrimerNeuroscienceExploitBiomimetic materialsNanomedicineCentral nervous systemFocused ultrasoundLiposomeBiocompatible materialMaterials scienceMedicineDendrimers and Hyperbranched PolymersRNA Interference and Gene DeliveryBrain Tumor Detection and Classification