Antibacterial Effect of Caffeic Acid Phenethyl Ester on Cariogenic Bacteria and Streptococcus mutans Biofilms
Yumei Niu, Kun Wang, Sainan Zheng, Yufei Wang, Qian Ren, Haoran Li, Longjiang Ding, Wei Li, Linglin Zhang
Abstract
Dental caries is the most common disease in the human mouth. Streptococcus mutans is the primary cariogenic bacterium. Propolis is a nontoxic natural product with a strong inhibitory effect on oral cariogenic bacteria. The polyphenol-rich extract from propolis inhibits S. mutans growth and biofilm formation, as well as the genes involved in virulence and adherence, through the inhibition of glucosyltransferases (GTF). However, because the chemical composition of propolis is highly variable and complex, the mechanism of its antimicrobial action and the active compound are controversial and not completely understood.
Topics & Concepts
PropolisStreptococcus mutansCaffeic acid phenethyl esterBiofilmMicrobiologyBacteriaAntimicrobialChemistryPolyphenolCaffeic acidNatural productBiologyBiochemistryFood scienceAntioxidantGeneticsBee Products Chemical AnalysisEssential Oils and Antimicrobial ActivityMedical and Biological Ozone Research