Integrative epigenomic analyses of small cell lung cancer cells demonstrates the clinical translational relevance of gene body methylation
Lőrinc Sándor Pongor, Camille Tlemsani, Fathi Elloumi, Yasuhiro Arakawa, Ukhyun Jo, Jacob Gross, Sara Mosavarpour, Sudhir Varma, Rahul K. Kollipara, Nitin Roper, Beverly A. Teicher, Mirit I. Aladjem, William C. Reinhold, Anish Thomas, John D. Minna, Jane E. Johnson, Yves Pommier
Abstract
, using H3K27ac and NEUROD1, ASCL1, and POU2F3 ChIP-seq data, we show that genic methylation is inversely proportional to expression, thus providing a new approach to identify potential SE regulated genes involved in SCLC pathogenesis. To advance SCLC transitional research, these data are integrated into our web portal (https://discover.nci.nih.gov/SclcCellMinerCDB/) for open and easy access to basic and clinical investigators.
Topics & Concepts
DNA methylationMethylationEpigenomicsBiologyGeneEpigeneticsPromoterGene expressionEnhancerCancer researchRegulation of gene expressionGeneticsComputational biologyEpigenetics and DNA MethylationLung Cancer Research StudiesRNA modifications and cancer