Kidney Function, Kidney Function Decline, and the Risk of Dementia in Older Adults
Hong Xu, Sara García‐Ptacek, Marco Trevisan, Marie Evans, Bengt Lindholm, Maria Eriksdotter, Juan Jesús Carrero
Abstract
OBJECTIVE: Community-based reports regarding the association between the estimated glomerular filtration rate (eGFR) and dementia risk show conflicting results. The aim of this study is to investigate the links among kidney function, kidney function decline, and dementia incidence. METHODS: We analyzed the association of eGFR with the risk of dementia (defined as a new dementia diagnosis or initiation of dementia treatments) among 329,822 residents of Stockholm who accessed health care during 2006 to 2011, were ≥65 years of age, had no history of dementia, or underwent kidney replacement therapy. We also estimated the rate of eGFR decline among 205,622 residents with repeated eGFR measurements during the first year of observation and investigated its association with subsequent dementia risk. RESULTS: , a proportion higher than that attributed to other dementia risk factors such as cardiovascular disease and diabetes. CONCLUSIONS: Both lower kidney function and steeper kidney function decline are associated with the development of dementia.