High Throughput Sequencing for Clinical Tuberculosis: An Overview
Tara Ness, Andrew R. DiNardo, Maha Farhat
Abstract
High throughput sequencing (HTS) can identify the presence of Mycobacterium tuberculosis DNA in a clinical sample while also providing information on drug susceptibility. Multiple studies have provided a context for exploring the clinical application of HTS for TB diagnosis. The workflow challenges, strengths and limitations of the various sequencing platforms, and tools used for analysis are presented to provide a framework for further innovations in the field.
Topics & Concepts
WorkflowDNA sequencingContext (archaeology)TuberculosisThroughputComputational biologyMycobacterium tuberculosisComputer scienceClinical microbiologyMedicineBiologyDNAGeneticsDatabaseMicrobiologyPathologyWirelessTelecommunicationsPaleontologyMycobacterium research and diagnosisTuberculosis Research and EpidemiologyGenomics and Phylogenetic Studies