Multiple sclerosis-related fatigue: the role of impaired corticospinal responses and heightened exercise fatigability
Kyla Coates, Saied Jalal Aboodarda, Renata Lopes Krüger, Tristan Martin, Luanne M. Metz, Scott E. Jarvis, Guillaume Y. Millet
Abstract
The etiology of fatigability from whole body exercise was examined for the first time to accurately elucidate the relationship between fatigue and fatigability in multiple sclerosis (MS). Compromised corticospinal responsiveness predicted fatigue severity, providing a novel, objective indicator of fatigue in MS. Although the impaired corticomotor transmission did not aggravate muscle activation in this group of people with multiple sclerosis (PwMS) of lower disability, heightened muscle fatigability was seen to contribute to perceptions of fatigue in PwMS.
Topics & Concepts
Multiple sclerosisPhysical medicine and rehabilitationMuscle fatigueMedicinePsychologyPhysical therapyNeuroscienceElectromyographyPsychiatryMultiple Sclerosis Research StudiesPeripheral Neuropathies and DisordersAutoimmune and Inflammatory Disorders Research