The transcription factor Bcl11b promotes both canonical and adaptive NK cell differentiation
Tim D. Holmes, Ram Vinay Pandey, Eric Y. Helm, Heinrich Schlums, Hongya Han, Tessa M. Campbell, Theodore T. Drashansky, Samuel C. C. Chiang, Cheng-Ying Wu, Christine Tao, Moneef Shoukier, Eva Tolosa, Sandra von Hardenberg, Miao Sun, Christian Klemann, Rebecca Marsh, Colleen M. Lau, Yin C. Lin, Joseph C. Sun, Robert Månsson, Frank Cichocki, Dorina Avram, Yenan T. Bryceson
Abstract
was required for adaptive NK cell responses in a murine cytomegalovirus model, supporting expansion of these cells. Together, we define the TF regulatory circuitry of human NK cells and uncover a critical role for Bcl11b in promoting NK cell differentiation and function.
Topics & Concepts
BiologyTranscription factorEpigeneticsCell biologyEctopic expressionCellular differentiationCellGeneGeneticsImmune Cell Function and InteractionT-cell and B-cell ImmunologyCAR-T cell therapy research