A thermosensitive, reactive oxygen species-responsive, MR409-encapsulated hydrogel ameliorates disc degeneration in rats by inhibiting the secretory autophagy pathway
Qiangqiang Zheng, Haotian Shen, Zongrui Tong, Linxiang Cheng, Yuzi Xu, Zhiyun Feng, Shiyao Liao, Xiaojian Hu, Zongyou Pan, Zhengwei Mao, Yue Wang
Abstract
Secretory autophagy and associated IL-1β secretion contribute to the pathogenesis of disc degeneration, and MR409 can effectively inhibit this pathway. The ROS-responsive thermosensitive hydrogel encapsulated with MR409 is a potentially efficacious treatment for disc degeneration.
Topics & Concepts
AutophagyReactive oxygen speciesDegeneration (medical)Cell biologyChemistrySecretionOxygenBiochemistryPathologyMedicineBiologyApoptosisOrganic chemistrySpine and Intervertebral Disc PathologySpinal Hematomas and ComplicationsSpinal Cord Injury Research