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Discovery of phthalazino[1,2-b]-quinazolinone derivatives as multi-target HDAC inhibitors for the treatment of hepatocellular carcinoma via activating the p53 signal pathway

Qingqing Liu, Bin Zhang, Yuanjiang Wang, Xinyi Wang, Shao-Hua Gou

2021European Journal of Medicinal Chemistry41 citationsDOIOpen Access PDF

Topics & Concepts

ChemistryVorinostatQuinazolinoneHydroxamic acidHistone deacetylaseAcetylationHDAC1Hepatocellular carcinomaCancer researchIn vivoToxicityHistoneIC50PharmacologyIn vitroBiochemistryStereochemistryBiologyGeneOrganic chemistryBiotechnologyHistone Deacetylase Inhibitors ResearchProtein Degradation and InhibitorsClick Chemistry and Applications
Discovery of phthalazino[1,2-b]-quinazolinone derivatives as multi-target HDAC inhibitors for the treatment of hepatocellular carcinoma via activating the p53 signal pathway | Litcius