Achieving red-light anticancer photodynamic therapy under hypoxia using Ir(<scp>iii</scp>)–COUPY conjugates
Enrique Ortega, Anna Rovira, Pezhman Ashoo, E. Izquierdo, Cormac Hally, Diego Abad-Montero, Mireia Jordà-Redondo, Gloria Vigueras, Alba Deyà, José L. Hernández, Jorge Galino, Manel Bosch, Marta E. Alberto, Antonio Francés‐Monerris, Santi Nonell, José Ruiz, Vicente Marchán
Abstract
Conjugation of COUPY dyes to cyclometalated Ir( iii ) complexes is a strategy at the frontier of the development of red-light-activated photosensitizers capable of operating under challenging hypoxic conditions, showing the promise of anticancer PDT.
Topics & Concepts
Photodynamic therapyHypoxia (environmental)ConjugateChemistryCancer researchPharmacologyMedicineOxygenOrganic chemistryMathematicsMathematical analysisNanoplatforms for cancer theranosticsPhotodynamic Therapy Research StudiesCancer, Hypoxia, and Metabolism