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Impact of In Vitro Passive Permeability in a P-gp-transfected LLC-PK1 Model on the Prediction of the Rat and Human Unbound Brain-to-Plasma Concentration Ratio

Johan Nicolaï, Hélène Chapy, Eric Gillent, Kenneth Saunders, Anna‐Lena Ungell, Jean‐Marie Nicolas, Hugues Chanteux

2020Pharmaceutical Research17 citationsDOI

Topics & Concepts

In vivoIn vitroPharmacologyChemistryBlood–brain barrierPharmacokineticsPermeability (electromagnetism)Drug discoveryP-glycoproteinBiophysicsBiochemistryMedicineBiologyMembraneInternal medicineCentral nervous systemMultiple drug resistanceBiotechnologyAntibioticsDrug Transport and Resistance MechanismsPharmacological Effects and Toxicity StudiesNeuroscience and Neuropharmacology Research
Impact of In Vitro Passive Permeability in a P-gp-transfected LLC-PK1 Model on the Prediction of the Rat and Human Unbound Brain-to-Plasma Concentration Ratio | Litcius