Intervention with methotrexate in patients with arthralgia at risk of rheumatoid arthritis to reduce the development of persistent arthritis and its disease burden (TREAT EARLIER): a randomised, double-blind, placebo-controlled, proof-of-concept trial

Doortje I Krijbolder, Marloes Verstappen, Bastiaan T van Dijk, Yousra J. Dakkak, L.E. Burgers, Aleid C. Boer, Yune Jung Park, Marianne E de Witt-Luth, Karen Visser, Marc R. Kok, Esmeralda T. H. Molenaar, Pascal H P de Jong, Stefan Böhringer, T. Huizinga, Cornelia F Allaart, Ellis Niemantsverdriet, Annette H M van der Helm–van Mil