A Biocatalytic Platform for the Synthesis of Enantiopure Propargylic Alcohols and Amines
Xianke Sang, Feifei Tong, Zhigang Zeng, Minghu Wu, Bo Yuan, Zhoutong Sun, Xiang Sheng, Ge Qu, Miguel Alcalde, Frank Hollmann, Wuyuan Zhang
Abstract
was established. The one-pot two-step cascade reaction yielded a broad range of enantioenriched alcohol and amine products in 70-99% yield.
Topics & Concepts
ChemistryEnantiopure drugAlcoholOrganic chemistryAmine gas treatingAlcohol dehydrogenaseEnantioselective synthesisBiocatalysisAspergillus terreusYield (engineering)TransaminaseCombinatorial chemistryEnzymeCatalysisReaction mechanismFood scienceMetallurgyMaterials scienceEnzyme Catalysis and ImmobilizationChemical Synthesis and AnalysisMicrobial Natural Products and Biosynthesis