Synthesis of quinazolinone scaffolds <i>via</i> a zinc(<scp>ii</scp>)-stabilized amidyl radical-promoted deaminative approach
Subarna Manna, Sangita Sahoo, Arnab Rit
Abstract
We report an exclusively ligand-based redox controlled deaminative coupling of o -amino amides/esters with nitriles utilizing a bench stable Zn-compound to produce diverse quinazolinones including synthons for therapeutically relevant compounds.
Topics & Concepts
QuinazolinoneChemistryCombinatorial chemistryZincLigand (biochemistry)Broad spectrumOrganic chemistryBiochemistryReceptorQuinazolinone synthesis and applicationsSynthesis and Biological EvaluationAdvanced Synthetic Organic Chemistry