Glucose-6-Phosphate Acts as an Extracellular Signal of SagS To Modulate <i>Pseudomonas aeruginosa</i> c-di-GMP Levels, Attachment, and Biofilm Formation
So‐Young Park, Jozef Dingemans, Madison Gowett, Karin Sauer
Abstract
Pathogens sense and respond to signals and cues present in their environment, including host-derived small molecules to modulate the expression of their virulence repertoire. Here, we demonstrate that the opportunistic pathogen Pseudomonas aeruginosa responds to glucose-6-phosphate.
Topics & Concepts
BiofilmPseudomonas aeruginosaExtracellularChemistryMicrobiologyPhosphatePseudomonadalesBiochemistryCell biologyBacteriaBiologyGeneticsBacterial biofilms and quorum sensingLegionella and Acanthamoeba researchOral microbiology and periodontitis research