Sensitive sensing of alkaline phosphatase and γ-glutamyltranspeptidase activity for tumor imaging
Yanyun Yang, Miaomiao Zhang, Wenting Zhang, Yinglu Chen, Tong Zhang, Sheng Chen, Yue Yuan, Gaolin Liang, Shusheng Zhang
Abstract
for GGT. Eventually, the BL probe P-Bz-Luc was successfully applied for sensitive imaging of the ALP and GGT co-overexpressed fLuc-231 breast cancer cells and tumors, with the help of the coordination cleavage of P-Bz-Luc by ALP and GGT.
Topics & Concepts
Alkaline phosphataseChemistryIn vivoCleavage (geology)BioluminescenceIn vitroMolecular biologyEnzymeBiochemistryBiologyFracture (geology)BiotechnologyPaleontologyNanoplatforms for cancer theranosticsbioluminescence and chemiluminescence researchAdvanced biosensing and bioanalysis techniques