First atroposelective Chan–Lam coupling for the synthesis of C–N linked biaryls
Moeka Ishida, Rina Adachi, Kazuki Kobayashi, Yukiko Yamamoto, Chinatsu Kawahara, Tsuyoshi Yamada, Hiroshi Aoyama, Kyohei Kanomata, Shuji Akai, Patrick Y. S. Lam, Hironao Sajiki, Takashi Ikawa
Abstract
additive is crucial for the success of the coupling. The longstanding problem of the lack of enantioselective synthesis to make chiral C-N linked atropisomers is solved.
Topics & Concepts
AtropisomerEnantiomerEnantioselective synthesisCoupling (piping)ChemistryStereochemistryCombinatorial chemistryOrganic chemistryCatalysisMaterials scienceMetallurgyAxial and Atropisomeric Chirality SynthesisMolecular spectroscopy and chiralityChemical synthesis and alkaloids