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Therapeutically reprogrammed nutrient signalling enhances nanoparticulate albumin bound drug uptake and efficacy in KRAS-mutant cancer

Ran Li, Thomas S.C. Ng, Stephanie J. Wang, Mark Prytyskach, Christopher B. Rodell, Hannes Mikula, Rainer H. Köhler, Michelle A. Garlin, Douglas A. Lauffenburger, Sareh Parangi, Daniela M. Dinulescu, Nabeel Bardeesy, Ralph Weissleder, Miles A. Miller

2021Nature Nanotechnology120 citationsDOIOpen Access PDF

Topics & Concepts

MutantKRASDrugCancerCancer researchCancer drugsSignallingAlbuminChemistryCell biologyBiologyPharmacologyMutationBiochemistryGeneGeneticsMetabolism, Diabetes, and CancerCancer, Hypoxia, and MetabolismCancer-related Molecular Pathways
Therapeutically reprogrammed nutrient signalling enhances nanoparticulate albumin bound drug uptake and efficacy in KRAS-mutant cancer | Litcius