B-Cell Compartmental Features and Molecular Basis for Therapy in Autoimmune Disease
Chao Zhang, Tianxiang Zhang, Ye Liu, Dongmei Jia, Pei Zeng, Du Chen, Meng Yuan, Qiang Liu, Yongjun Wang, Fu‐Dong Shi
Abstract
BACKGROUND AND OBJECTIVES: To assess the molecular landscape of B-cell subpopulations across different compartments in patients with neuromyelitis optica spectrum disorder (NMOSD). METHODS: We performed B-cell transcriptomic profiles via single-cell RNA sequencing across CSF, blood, and bone marrow in patients with NMOSD. RESULTS: ASCs could be ablated by tocilizumab, but not rituximab treatment in NMOSD. DISCUSSION: B cells are compartmentally fine tuned toward autoreactivity in NMOSD and become hyperreactive to type I interferon. Inhibition of type I interferon pathway may provide a new therapeutic avenue for NMOSD.
Topics & Concepts
DiseaseBasis (linear algebra)Autoimmune diseaseComputational biologyMedicineImmunologyComputer scienceBiologyInternal medicineMathematicsGeometryT-cell and B-cell ImmunologyMonoclonal and Polyclonal Antibodies ResearchSystemic Lupus Erythematosus Research