Trapping of protein cargo molecules inside DNA origami nanocages
Merle Scherf, Florian Scheffler, Christopher Maffeo, Ulrich Kemper, Jingjing Ye, Aleksei Aksimentiev, Ralf Seidel, Uta Reibetanz
Abstract
DNA nanocages are developed for the encapsulation and delivery of freely diffusing drug cargo molecules. The cargo was attached to the nanotube, and subsequently detached via toehold-mediated strand displacement after tube sealing with lids.
Topics & Concepts
NanocagesDNADNA nanotechnologyMoleculeNanotechnologyA-DNADNA origamiBiophysicsChemistryMaterials scienceBiochemistryBiologyCatalysisOrganic chemistryAdvanced biosensing and bioanalysis techniquesRNA Interference and Gene DeliveryBacteriophages and microbial interactions