A Pivotal Role for Mycobactin/ <i>mbtE</i> in Growth and Adaptation of Mycobacterium abscessus
Mark Foreman, Ilana Kolodkin‐Gal, Daniel Barkan
Abstract
-mutant is comparable to the response of the parental strain to iron starvation and seems different from the response of M. tuberculosis. These results indicate the importance of studying mycobactin in M. abscessus and NTM strains. Understanding this pathway is central to understanding the acquisition of iron within hosts and its role in pathogenesis, which in turn may facilitate the development of antimycobacterial therapeutics.
Topics & Concepts
MutantHeminMicrobiologySiderophoreBiologyMycobacterium tuberculosisMycobacterium abscessusBacteriaTranscriptomeEffluxWild typeGene clusterGene expressionGeneMycobacteriumGeneticsTuberculosisBiochemistryMedicineHemeEnzymePathologyMycobacterium research and diagnosisPharmacological Effects of Natural CompoundsTuberculosis Research and Epidemiology