Exosomal circRNAs contribute to intestinal development via the VEGF signalling pathway in human term and preterm colostrum
Yahui Zhou, Zhangbin Yu, Xingyun Wang, Wenjuan Chen, Yiwen Liu, Yinghui Zhang, Jing Yin, Shuping Han
Abstract
in PC. Pathway analysis showed that the VEGF signalling pathway was involved, and network analysis revealed that the differentially expressed circRNAs bound various miRNAs. Further analyses showed that has_circRNA_405708 and has_circRNA_104707 were involved in the VEGF signalling pathway, and that they all bound various mirRNAs. Exosomes found in preterm colostrum (PC) and term colostrum (TC) promoted VEGF protein expression and induced the proliferation and migration of small intestinal epithelial cells (FHCs). Exosomal circRNAs found in human colostrum (HC) binding to related miRNAs may regulate VEGF signalling, and intestinal development.
Topics & Concepts
ColostrumVEGF receptorsCell biologySignalling pathwaysSignallingSignal transductionMedicineBiologyImmunologyCancer researchAntibodyCircular RNAs in diseasesCongenital Anomalies and Fetal SurgeryExtracellular vesicles in disease