Quantifiable polarity match effect on C–H bond cleavage reactivity and its limits in reaction design
Mauricio Maldonado‐Domínguez, Martin Srnec
Abstract
When oxidants favour cleaving a strong C–H bond at the expense of weaker ones, which are otherwise inherently preferred due to their favourable reaction energy, reactivity factors such as the polarity match effect are often invoked.
Topics & Concepts
ElectrophileReactivity (psychology)NucleophileChemistryPolarity (international relations)A priori and a posterioriBond cleavageComputational chemistryStereochemistryCatalysisOrganic chemistryEpistemologyAlternative medicineCellMedicinePhilosophyPathologyBiochemistryCatalytic C–H Functionalization MethodsSynthesis and Catalytic ReactionsSulfur-Based Synthesis Techniques