Discovery of mitochondrion-targeting copper(<scp>ii</scp>)-plumbagin and -bipyridine complexes as chemodynamic therapy agents with enhanced antitumor activity
Hai-Qun Zhang, Xing Lü, Jiang-Lun Wu, Mei-Quan Ou, Nan-Feng Chen, Hong Liang, Zhen‐Feng Chen
Abstract
Four complexes (Cu1–Cu4) that consume glutathione (GSH) were synthesized as mitochondrion-targeting antitumor agents with enhanced chemodynamic therapy (CDT),exhibiting strong anti-tumor activity both in vitro and in vivo .
Topics & Concepts
PlumbaginChemistryHydrogen peroxideHeLaApoptosisMitochondrionRadicalIn vivoReactive oxygen speciesPenicillamineHydroxyl radicalIn vitroBiochemistryCell biologyBiologyOrganic chemistryGeneticsBiotechnologyNanoplatforms for cancer theranosticsBioactive Compounds and Antitumor AgentsMetal complexes synthesis and properties