PASylated Urate Oxidase Enzyme: Enhancing Biocatalytic Activity, Physicochemical Properties, and Plasma Half-Life
Abbas Najjari, Hamid Shahbazmohammadi, Seyed Ali Nojoumi, Eskandar Omidinia
Abstract
UOX fused with a C-terminally 100 amino acid PAS-residue, is a proper candidate with enhanced biological activity and extended plasma half-life for clinical therapy in patients suffering from hyperuricemia.
Topics & Concepts
ChemistryUrate oxidaseEnzyme kineticsEnzymeBiochemistryChromatographyActive siteGout, Hyperuricemia, Uric AcidPorphyrin Metabolism and DisordersMethemoglobinemia and Tumor Lysis Syndrome