Advances in understanding of angioimmunoblastic T-cell lymphoma
Shigeru Chiba, Mamiko Sakata‐Yanagimoto
Abstract
It has been nearly half a century since angioimmunoblastic T-cell lymphoma (AITL) was characterized in the early 1970's. Our understanding of the disease has dramatically changed due to multiple discoveries and insights. One of the key features of AITL is aberrant immune activity. Although AITL is now understood to be a neoplastic disease, pathologists appreciated that it was an inflammatory condition. The more we understand AITL at cellular and genetic levels, the more we view it as both a neoplastic and an inflammatory disease. Here, we review recent progress in our understanding of AITL, focusing on as yet unsolved questions.
Topics & Concepts
Angioimmunoblastic T-cell lymphomaLymphomaMedicineCancer researchBiologyImmunologyT cellImmune systemVascular Tumors and AngiosarcomasLymphoma Diagnosis and TreatmentAcute Myeloid Leukemia Research