Pyrazoline Containing Compounds as Therapeutic Targets for Neurodegenerative Disorders
Mohamed Jawed Ahsan, Amena Ali, Abuzer Ali, Arunkumar Thiriveedhi, Md. Afroz Bakht, Mohammad Yusuf, Salahuddin Salahuddin, Obaid Afzal, Abdulmalik Saleh Alfawaz Altamimi
Abstract
) plaques. They were discovered to be efficient against PD and also targeted MAO B and COMT. It was discovered that the pyrazolines block MAO A to treat psychiatric diseases. Pyrazolines are significant heteroaromatic scaffolds with a variety of biological functions. They were discovered to be remarkably stable and serve as an indispensable anchor for the development of new drugs. By blocking AChE and MAOs, they may be used to treat neurodegenerative diseases. The discussion outlined here is an essential and helpful resource for medicinal chemists who are investigating and applying pyrazolines in neurodegenerative research initiatives as well as to expedite future research programs on neurodegenerative disorders.