Experimental Evolution Identifies Adaptive Aneuploidy as a Mechanism of Fluconazole Resistance in Candida auris
Jian Bing, Tianren Hu, Qiushi Zheng, José F. Muñoz, Christina A. Cuomo, Guanghua Huang
Abstract
Candida auris is a newly emerging fungal pathogen of humans and has attracted considerable attention from both the clinical and basic research communities. Clinical isolates of C. auris are often resistant to one or more antifungal agents. To explore how antifungal resistance develops, we performed experimental evolution assays using a fluconazole-susceptible isolate of C. auris (BJCA001). After a series of passages through medium containing increasing concentrations of fluconazole, fungal cells acquired resistance.
Topics & Concepts
Candida aurisFluconazoleFungal pathogenBiologyAntifungalMicrobiologyPathogenMechanism (biology)PhilosophyEpistemologyAntifungal resistance and susceptibilityFungal Infections and StudiesPneumocystis jirovecii pneumonia detection and treatment