The salivary exosomal microRNA as a potential biomarker in patients with periodontitis and oral cancers
Zahra Safari, Alireza Firouzi, Nika Rezaeikalantari, Sanaz Mohammadi, Nikta Ranjbar, Hooman Shahpori, Pouya Khaleghi, Mobina Bagherianlemraski, Shakiba Zandi, Sona Rafieyan
Abstract
Periodontitis and oral cancers are the most common oral diseases in the human population. The early diagnosis of oral diseases allows the efficient therapy of the patient. During oral diseases, resident cells in the affected tissue secrete exosomal microRNAs (miRNAs) into saliva. As these miRNAs have a crucial role in the pathogenesis of oral diseases, they have been suggested as non-invasive and validated biomarkers in predicting periodontitis severity and cancer progression. Several attempts have been performed to evaluate the expression of salivary exosomal miRNAs in patients with periodontitis and oral cancers. Some miRNAs are differentially expressed in the saliva of the affected patients when compared to healthy individuals. These miRNAs are reviewed in this narrative review. Collectively, it seems that salivary exosomal microRNAs could be used as a diagnostic biomarker in oral diseases. However, further studies are required to validate them.