Structural and Genomic Evolution of RRNPPA Systems and Their Pheromone Signaling
Alonso Felipe-Ruíz, Alberto Marina, Eduardo P. C. Rocha
Abstract
, the most important family of QS receptors is the RRNPPA family. Despite the importance of such systems in microbiology, we know little about RRNPPA origin and diversification. In this work, the combination of sequence analysis and structural biology allowed us to identify a very large number of novel systems but also to class of them in functional families and thereby study of their origin and functional diversification. Moreover, peptide pheromone analysis revealed new and intriguing mechanisms of communication, such as "eavesdropper" systems which only listen for the pheromone and "chatterers" that take control of the communication in their microenvironment.
Topics & Concepts
BiologyQuorum sensingGeneticsPlasmidMobile genetic elementsHorizontal gene transferGeneVirulenceProphagePhylogeneticsComparative genomicsBacteriophageEvolutionary biologyComputational biologyGenomicsGenomeEscherichia coliBacterial biofilms and quorum sensingBacillus and Francisella bacterial researchBacterial Genetics and Biotechnology