Moderate mechanical stimulation rescues degenerative annulus fibrosus by suppressing caveolin-1 mediated pro-inflammatory signaling pathway
Weidong Zhang, Huan Wang, Zhangqin Yuan, Genglei Chu, Heng Sun, Zilin Yu, Huan Liang, Tao Liu, Feng Zhou, Bin Li
Abstract
results, this study expounds the underlying molecular mechanisms on the effect of moderate mechanical stimulation on intervertebral discs (IVDs) and may provide a new therapeutic strategy for the treatment of IVD degeneration.
Topics & Concepts
MechanotransductionStimulationIn vivoCell biologyCaveolin 1Extracellular matrixInflammationSignal transductionChemistryMedicineBiologyImmunologyInternal medicineBiotechnologySpine and Intervertebral Disc PathologyShoulder Injury and TreatmentCervical and Thoracic Myelopathy